Corresponding/First authored papers (#co-first author, *Corresponding author)

1.Xiang Li#*, Yating Cao#, Fei Xu#, Yiting Zhang, Yue Kong, Chengjie Lan, Rongfeng Zhu, Cheng Lin, Chuan-Qi Zhong, Zhilong Liu, Hong Qi, Yichuan Huang, Yunshan Xiao, Gui-Quan Sun, Jianwei Shuai*, Xin Chen*. Decoding necrosome assembly: harmonizing signal amplification and attenuation through optimal RIP3 stoichiometry. Nat Commun. 2025 Dec 23;17(1):405. doi: 10.1038/s41467-025-67098-5.

2. Zhuang R#, Zhou Y#, Wang Z, Cao Y, Chen J, Xu L, Ren Y, Zheng Y, Wei Z, Qiu H, Li L, Han Y, Yun Y, Chen X*, Hong W*, Wang T*. Rab26 restricts insulin secretion via sequestering Synaptotagmin-1. PLoS Biol.2023 Jun 8;21(6):e3002142. doi: 10.1371/journal.pbio.3002142.

3. Chen X*, Zhu R, Zhong J, Ying Y, Wang W, Cao Y, Cai H, Li X, Shuai J, Han J*. Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death. Nat Cell Biol.2022 Apr;24(4):471-482. PMID: 35256774. doi: 10.1038/s41556-022-00854-7. Epub 2022 Mar 7. (previewed in Nature Cell Biology: “RIPK1 and RIPK3 form mosaic necrosomes”).

4. Xue Z, Wang S, Li J, Chen X*, Han J, Han S*. Bifunctional Super-resolution Imaging Probe with Acidity-independent Lysosome-retention Mechanism. Anal Chem. 2018 Oct 2;90(19):11393-11400. PMID: 30148356. doi: 10.1021/acs.analchem.8b02365. Epub 2018 Sep 10.

5. Chen X#, He WT#, Hu L, Li J, Fang Y, Wang X, Xu X, Wang Z, Huang K, Han J*. Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res. 2016 Sep;26(9):1007-20. PMID: 27573174. doi: 10.1038/cr.2016.100. Epub 2016 Aug 30.

6. Chen X#, Li W#, Ren J#, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J*. Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res. 2014 Jan;24(1):105-21. PMID: 24366341. doi: 10.1038/cr.2013.171. Epub 2013 Dec 24. (highlighted by Cell Research: “MLKL regulates necrotic plasma membrane permeabilization”, and Nature Reviews Molecular Cell Biology; regarded as a highly cited paper by Web of Science).

7. Chen X#, Ma JJ#, Tan M, Yao P, Hu QH, Eriani G, Wang ED*. Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase. Nucleic Acids Res. 2011 Jan;39(1):235-47. PMID: 20805241. doi: 10.1093/nar/gkq763. Epub 2010 Aug 30.

Co-authored papers

1. Wu Z, Wang Y, Chen WW, Sun H, Chen X, Li X, Wang Z, Liang W, Wang SY, Luan X, Li Y, Huang S, Liang Y, Zhang J, Chen ZF, Wang G, Gao Y, Liu Y, Wang J, Liu Z, Shi P, Liu C, Lv L, Hou A, Wu C, Yao C, Hong Z, Dai J, Lu Z, Pan F, Chen X, Kettenmann H, Amit I, Speakman JR, Chen Y, Ginhoux F, Cui R, Huang T, Li H. Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution. Cell.2025 Apr 17;188(8):2159-2174.e15. doi: 10.1016/j.cell.2025.02.007.

2. Han T, Ruan C, Lin H, Zhang Y, Li L, Sun YH, Zhong CQ, Chen X, Huang K, Cao Y, Fan Z, Zhang H, Han J, Zhang Y. RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice.J Exp Med. 2025 Dec 1;222(12):e20250277. doi: 10.1084/jem.20250277.

3. Wang Y, Zhang Q, He T, Wang Y, Lu T, Wang Z, Wang Y, Lin S, Yang K, Wang X, Xie J, Zhou Y, Hong Y, Liu WH, Mao K, Cheng SC, Chen X, Li Q, Xiao N. The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells. Nat Commun. 2023 Oct 20;14(1):6639. PMID: 37863917. doi: 10.1038/s41467-023-42428-7

4. Peng GX, Mao XL, Cao Y, Yao SY, Li QR, Chen X, Wang ED, Zhou XL. RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation. Nucleic Acids Res.2022 Dec 9;50(22):12951-12968. PMID: 36503967. doi: 10.1093/nar/gkac1141.

5. Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q. Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis. Mol Cell. 2022 May 19;82(10):1821-1835.e6. PMID: 35381197. doi: 10.1016/j.molcel.2022.03.016. Epub 2022 Apr 4.

6. Zhou X#, Ma F#, Xie J#, Yuan M#, Li Y#, Shaabani N#, Zhao F, Huang D, Wu NC, Lee CD, Liu H, Li J, Chen Z, Hong Y, Liu WH, Xiao N, Burton DR, Tu H, Li H, Chen X, Teijaro JR, Wilson IA*, Xiao C*, Huang Z*. Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2. Cell Rep. 2021 May 11;35(6):109109. PMID: 33932326. doi: 10.1016/j.celrep.2021.109109. Epub 2021 Apr 24.

7. Li X#, Zhong CQ#, Wu R#, Xu X, Yang ZH, Cai S, Wu X, Chen X, Yin Z, He Q, Li D, Xu F, Yan Y, Qi H, Xie C, Shuai J*, Han J*. RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes. Protein & Cell. 2021 Nov;12(11):858-876. PMID: 33389663. doi: 10.1007/s13238-020-00810-x. Epub 2021 Jan 2.

8. Li M#, Zhang CS#, Zong Y#, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC*. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. Cell Metab. 2019;30(3):508-524.e12. PMID: 31204282. doi:10.1016/j.cmet.2019.05.018. Epub 2019 Jun 13.

9. Wang P#, Geng J#, Gao J, Zhao H, Li J, Shi Y, Yang B, Xiao C, Linghu Y, Sun X, Chen X, Hong L, Qin F, Li X, Yu JS, You H, Yuan Z, Zhou D, Johnson RL, Chen L*. Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis. Nat Commun. 2019 Feb 14;10(1):755. PMID: 30765703. doi: 10.1038/s41467-019-08680-6.

10. Gao H#, Yang Z#, Wang X#, Qian P, Hong R, Chen X, Su XZ, Cui H, Yuan J*. ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility. Curr Biol. 2018;28(17):2763–2776.e6. PMID: 30146157. doi:10.1016/j.cub.2018.06.069. Epub 2018 Aug 23.

11. Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J*. RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.Nat Cell Biol. 2018 Feb;20(2):186-197. PMID: 29358703. doi: 10.1038/s41556-017-0022-y. Epub 2018 Jan 22.

12. Zhang Y, Chen X, Gueydan C, Han J*. Plasma membrane changes during programmed cell deaths. Cell Res. 2018 Jan;28(1):9-21. PMID: 29076500. doi: 10.1038/cr.2017.133. Epub 2017 Oct 27. Review.

13. Zhang Y#, Su SS#, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J*. RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome. Nat Commun.2017 Feb 8;8:14329. PMID: 28176780. doi: 10.1038/ncomms14329.

14. Huang D#, Zheng X#, Wang ZA#, Chen X, He WT, Zhang Y, Xu JG, Zhao H, Shi W, Wang X, Zhu Y, Han J*. MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process. Mol Cell Biol. 2017;37(5):e00497-16. PMID: 27920255. doi: 10.1128/MCB.00497-16. Print 2017 Mar 1.

15. Wu XN#, Yang ZH#, Wang XK, Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J*. Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis. Cell Death Differ. 2014 Nov;21(11):1709-20. PMID: 24902902. doi: 10.1038/cdd.2014.77. Epub 2014 Jun 6.

16. Tan M, Zhu B, Liu RJ, Chen X, Zhou XL, Wang ED*. Interdomain communication modulates the tRNA-dependent pre-transfer editing of leucyl-tRNA synthetase. Biochem J. 2013 Jan 1;449(1):123-31. doi: 10.1042/BJ20121258.

17. Tan M#, Yan W#, Liu RJ, Wang M, Chen X, Zhou XL, Wang ED*. A naturally occurring nonapeptide functionally compensates for the CP1 domain of leucyl-tRNA synthetase to modulate aminoacylation activity. Biochem J. 2012 Apr 15;443(2):477-84. doi: 10.1042/BJ20111925.

18. Zhou XL, Tan M, Wang M, Chen X, Wang, ED*. Post-transfer editing by a eukaryotic leucyl-tRNA synthetase resistant to the broad-spectrum drug AN2690. Biochem J. 2010 Sep 1;430(2):325-33. doi: 10.1042/BJ20100474.

19. Tan M#, Zhu B#, Zhou XL, He R, Chen X, Eriani G, Wang ED*. tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase. J Biol Chem. 2010 Jan 29;285(5):3235-44. doi: 10.1074/jbc.M109.060616. Epub 2009 Nov 23.

20. He R, Zu LD, Yao P, Chen X, Wang ED*. Two non-redundant fragments in the N-terminal peptide of human cytosolic methionyl-tRNA synthetase were indispensable for the multi-synthetase complex incorporation and enzyme activity. Biochim Biophys Acta. 2009 Feb;1794(2):347-54. doi: 10.1016/j.bbapap.2008.11.003. Epub 2008 Nov 19.

中文期刊

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