Peer-reviewed publications (Citations = 2539, H-index = 15; updated 23/7/10)

(* Corresponding Author; # equal contribution)

1. Rab26 restricts insulin secretion via sequestering Synaptotagmin-1.

Zhuang R#, Zhou Y#, Wang Z, Cao Y, Chen J, Xu L, Ren Y, Zheng Y, Wei Z, Qiu H, Li L, Han Y, Yun Y, Chen X*, Hong W*, Wang T*.

PLoS Biol. 2023 Jun 8;21(6):e3002142.

2. RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation.

Peng GX, Mao XL, Cao Y, Yao SY, Li QR, Chen X, Wang ED, Zhou XL.

Nucleic Acids Res. 2022 Dec 9;50(22):12951-12968.

3. Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.

Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q.

Mol Cell. 2022 May 19;82(10):1821-1835.e6.

4. Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death.

Chen X*, Zhu R, Zhong J, Ying Y, Wang W, Cao Y, Cai H, Li X, Shuai J, Han J*.

Nat Cell Biol. 2022 Apr;24(4):471-482.

highlighted by Nature Cell Biology: “RIPK1 and RIPK3 form mosaic necrosomes”;

获2022中国光学领域十大社会影响力事件（Light10）提名奖

5. Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2.

Zhou X#, Ma F#, Xie J#, Yuan M#, Li Y#, Shaabani N#, Zhao F, Huang D, Wu NC, Lee CD, Liu H, Li J, Chen Z, Hong Y, Liu WH, Xiao N, Burton DR, Tu H, Li H, Chen X, Teijaro JR, Wilson IA*, Xiao C*, Huang Z*.

Cell Rep. 2021 May 11;35(6):109109.

6. RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes.

Li X#, Zhong CQ#, Wu R#, Xu X, Yang ZH, Cai S, Wu X, Chen X, Yin Z, He Q, Li D, Xu F, Yan Y, Qi H, Xie C, Shuai J*, Han J*.

Protein & Cell. 2021 Nov;12(11):858-876.

7. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.

Li M#, Zhang CS#, Zong Y#, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC*.

Cell Metab. 2019;30(3):508-524.e12.

8. Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis.

Wang P#, Geng J#, Gao J, Zhao H, Li J, Shi Y, Yang B, Xiao C, Linghu Y, Sun X, Chen X, Hong L, Qin F, Li X, Yu JS, You H, Yuan Z, Zhou D, Johnson RL, Chen L*.

Nat Commun. 2019 Feb 14;10(1):755.

9. Bifunctional Super-resolution Imaging Probe with Acidity-independent Lysosome-retention Mechanism.

Xue Z, Wang S, Li J, Chen X*, Han J, Han S*.

Anal Chem. 2018 Oct 2;90(19):11393-11400.

10. ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility.

Gao H#, Yang Z#, Wang X#, Qian P, Hong R, Chen X, Su XZ, Cui H, Yuan J*.

Curr Biol. 2018;28(17):2763–2776.e6.

11. RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.

Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J*.

Nat Cell Biol. 2018 Feb;20(2):186-197.

12. Plasma membrane changes during programmed cell deaths.

Zhang Y, Chen X, Gueydan C, Han J*.

Cell Res. 2018 Jan;28(1):9-21. PMID: 29076500. Review.

13. RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome.

Zhang Y#, Su SS#, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J*.

Nat Commun. 2017 Feb 8;8:14329.

14. MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process.

Huang D#, Zheng X#, Wang ZA#, Chen X, He WT, Zhang Y, Xu JG, Zhao H, Shi W, Wang X, Zhu Y, Han J*.

Mol Cell Biol. 2017;37(5):e00497-16.

15. Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis.

Chen X#, He WT#, Hu L, Li J, Fang Y, Wang X, Xu X, Wang Z, Huang K, Han J*.

Cell Res. 2016 Sep;26(9):1007-20.

highly cited (top 1% of the academic field of Molecular Biology & Genetics paper by Web of Science).

16. Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis.

Wu XN#, Yang ZH#, Wang XK, Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J*.

Cell Death Differ. 2014 Nov;21(11):1709-20.

17. Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death.

Chen X#, Li W#, Ren J#, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J*.

Cell Res. 2014 Jan;24(1):105-21.

highlighted by Cell Research: “MLKL regulates necrotic plasma membrane permeabilization”;

highly cited (top 1% of the academic field of Molecular Biology & Genetics paper by Web of Science).

18. Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase.

Chen X#, Ma JJ#, Tan M, Yao P, Hu QH, Eriani G, Wang ED*.

Nucleic Acids Res. 2011 Jan;39(1):235-47.